Santa Ana, CA – Multi Vehicle Crash on I-5/Tustin Ranch Rd Causes Injuries

Santa Ana, CA (April 22, 2025) – A serious multi-vehicle crash involving a semi-truck and two sedans occurred early Monday morning on the southbound side of Interstate 5 near Tustin Ranch Road in Santa Ana, leaving multiple individuals with injuries. The collision took place around 4:44 a.m. on April 21. According to the California Highway Patrol (CHP), the semi-truck collided with two smaller vehicles under still-unclear circumstances. The impact caused significant damage to the sedans, both of which were left disabled in the roadway.

Emergency personnel from the Orange County Fire Authority responded swiftly to the scene. The injured individuals were treated on-site by paramedics before being transported by ambulance to a nearby medical facility for further evaluation. The identities of the injured parties have not yet been released. Authorities are actively investigating the events that led to the collision and are urging any witnesses to come forward with information.

Our thoughts are with those injured in this accident, and we hope for their full and speedy recovery.