Santa Ana, CA – Two Injured in Multi-Vehicle Crash on I-5 S/SR-133

Santa Ana, CA  (November 10, 2025) –A traffic collision involving two vehicles on Interstate 5 South at State Route 133 left at least two people injured on Monday, November 10. The California Highway Patrol (CHP) reported that the crash involved a dark gray Mazda CX-30 and a dark gray Ford Focus. Both vehicles ended up on the right shoulder with visible front-end damage.

Emergency crews arrived promptly to assess the victims at the scene, providing medical aid before transporting one individual to a nearby hospital for further evaluation. The other driver sustained minor injuries but did not require hospitalization. CHP officers temporarily restricted traffic flow as they cleared debris and documented the scene. The cause of the crash remains under investigation.

We wish all those injured a speedy and full recovery.

If you’ve been injured in a car accident on I-5, our car accident lawyers can help you pursue rightful compensation. For immediate legal support, call (888) 511-4558 to speak directly with an experienced I-5 accident attorney.